CarboDB Lipopolysaccharide 1877
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Neisseria gonorrhoeae
[edit] Basic Structure
Gonococcal lipopolysaccharide (LPS) is a complex of at least three major antigenic determinants. The ceramide part consists of the following residues : β-D-GalpNAc-(1-->3)-β-D-Galp-(1-->4)-β-D-Glcp-(1-?)-CER-(?--/Ceramide/. The core oligosaccharide part consists of the following residues : α-D-GlcpNAc-(1-->2)-L-gro [branched to β-D-Galp-(1-->4)-β-D-Glcp-(1-->4)] -α-D-manHepp-(1-->3)-L-gro-α-D-manHepp-(1-->5)-Kdo. The other part consists of the following residues : β-D-GalpNAc-(1-->3)-β-D-Galp-(1-->4)-β-D-GlcpNAc-(1-->3)-β-D-Galp-(1-->4)-β-D-Glcp-(1-->4)-L-gro [branched to α-D-GlcpNAc-(1-->2)-L-gro-α-D-manHepp-(1-->3)] -α-D-manHepp-(1-->5)-Kdo
[edit] Proposed functions
It is an important virulence factor
[edit] Antigenic Nature used to produce antibodies
gonococcal outer membranes
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 2C7
[edit] Antibody type and class
IgG3
[edit] Assay System
ELISA, immunoblotting
[edit] Cross-reactivity
This Mab was broadly cross-reactive among Neisseria gonorrhoeae strains except among WR213, F62, 8038-5, DAV, 6611-33, GC33 and WR302
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
N/A
