PolysacDB Meningococcal polysaccharide group B 1577
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Meningococcal polysaccharide group B
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Neisseria meningitidis B (CN7783)
[edit] Basic Structure
It is a homopolymer of α(2-->8) sialic acid
[edit] Proposed functions
This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
[edit] Antigenic Nature used to produce antibodies
Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab MB-34
[edit] Antibody type and class
IgM
[edit] Assay System
radioimmunoassay, counter immunoelectrophoresis and agglutination
[edit] Cross-reactivity
N/A
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab conferred passive protection of mice infected with either Neisseria meningitidis group B or Escherichia coli K 1
