PolysacDB Lipopolysaccharide 2553
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Vibrio cholerae 569B Inaba
[edit] Basic Structure
The O-antigen part consists of (1-->2)-α-linked 4-amino-4,6-dideoxy-D-mannose (perosamine) whose amino group is acylated with 3-deoxy-L-glycero-tetronic acid. The terminal sugar in the Inaba O-antigen has a hydroxyl at the 2' position
[edit] Proposed functions
V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera
[edit] Antigenic Nature used to produce antibodies
Purified LPS
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab C6
[edit] Antibody type and class
IgG3
[edit] Assay System
enzyme-linked immunosorbent assay inhibition experiments
[edit] Cross-reactivity
This Mab was specific to Inaba 35 and 569B LPS only
[edit] Proposed epitopes
This Mab was specific to C antigen
[edit] Proposed Utility
This Mab had a good agglutinating capacity when tested against V. cholerae 0:1 strains
