PolysacDB Lipopolysaccharide 1516
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Klebsiella pneumoniae Friedlander 201
[edit] Basic Structure
O-1 side chain of the LPS is proposed to contain a disaccharide repeat unit consisting of [-α-D-Galp-(1->3)-β-D-Galf-] (1->4), where Gal is galactose
[edit] Proposed functions
These major cell surface antigens play important roles in the ability of the bacterium to evade host cell defenses
[edit] Antigenic Nature used to produce antibodies
formalinized whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab Ru-O1
[edit] Antibody type and class
IgG2b
[edit] Assay System
ELISA and invivo protection studies
[edit] Cross-reactivity
This Mab cross-reacted with LPS prepared from strains belonging to the O1 serogroup, O19b antigen of E. coli, which has been shown to be immunologically identical to Klebsiella O1 and O6 and O8 antigens
[edit] Proposed epitopes
O1 antigen seems to bea part of the epitope
[edit] Proposed Utility
This Mab showed invivo protection and significantly reduced bacterial dissemination to various organs as well as macroscopic and histologic pulmonary alterations
