PolysacDB Lipopolysaccharide 1183
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Bordetella pertusis 18530
[edit] Basic Structure
N/A
[edit] Proposed functions
The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties
[edit] Antigenic Nature used to produce antibodies
B. pertussis 18530 LPS
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 6-4-H6
[edit] Antibody type and class
IgG3
[edit] Assay System
ELISA
[edit] Cross-reactivity
This antibody cross-reacted with delipidated polysaccharide fragments (PS-1 and PS-2). did not react with LPS prepared from B. parapertussis and B. bronchiseptica. No cross-reactions were observed with strains of Branhamella catarrhalis, Neisseria meningitidis, Streptococcus miteor, Haemophilus influenza, or Legionella pneumophila
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab might be useful for the detection of soluble antigens and whole bacteria in clinical samples and for studies of the immunochemical structure of B. pertussis LPS.
