PolysacDB Lipopolysaccharide 1050

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Escherichia coli strain J5 (chemotype Rc)

[edit] Basic Structure

The core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

Whole cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 4

[edit] Antibody type and class

IgG2a

[edit] Assay System

ELISA, Limulus assay, invivo protection assay

[edit] Cross-reactivity

This antibody ross-reacted with Salmonella minnesota strain R5

[edit] Proposed epitopes

Terminal glucose residues

[edit] Proposed Utility

N/A

[edit] Weblink

[http://www.ncbi.nlm.nih.gov/pubmed/2455054 ?dopt=Abstract' PubMed]

[edit] External Links

• Link to PolysacDB database