PolysacDB Lipoologosaccharide band A of the LPS 1181
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipoologosaccharide band A of the LPS
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Bordetella pertusis 325
[edit] Basic Structure
N/A
[edit] Proposed functions
The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties
[edit] Antigenic Nature used to produce antibodies
partially purified preparations of fimbriae from B. pertussis 325
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab E8D8B1
[edit] Antibody type and class
IgG3
[edit] Assay System
Immunoblotting
[edit] Cross-reactivity
Four strains of Bordetella bronchiseptica and three strains of Bordetella parapertussis were not agglutinated, nor were other gram-negative bacteria, such as Escherichia coli, N.meningitidis, Neisseria gonorrhoeae, Salmonella typhimurium, and Haemophilus influenzae
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab specifically agglutinated the bacteria. It could be useful in establishing a better-defined serotyping system for B. pertussis in which LOS A might be considered a typing antigen. This Mab can also be useful for the estimation of contaminating levels of endotoxin in vaccine preparations and for further studies on the structure of B. pertussis LOS.
