PolysacDB Capsular polysaccharide D 1027
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Capsular polysaccharide D
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Cryptococcus neoformans
[edit] Basic Structure
The capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated
[edit] Proposed functions
The capsular polysaccharide is an important virulence factor
[edit] Antigenic Nature used to produce antibodies
Glycoconjugates
[edit] Carrier Name
Sheep erythrocytes
[edit] Conjugation Method
The capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature
[edit] Antibodies
Mab 302
[edit] Antibody type and class
IgG1
[edit] Assay System
Ouchterlony double immunodiffusion, Phagocytosis assays
[edit] Cross-reactivity
This antibody cross-reacted with 2 serotypes- A and D
[edit] Proposed epitopes
The reactivity of this antibody required acetylation of the parent polysaccharide. Hence proposed epitopes may be O-acetyl groups
[edit] Proposed Utility
MAb against an epitope shared by all four serotypes may have value for the detection of cryptococcal antigens in body fluids. This antibody also has potent opsonic activity
