PolysacDB Capsular polysaccharide 500 antigen 1376
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Capsular polysaccharide 500 antigen
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Cryptosporidium parvum
[edit] Basic Structure
CPS-500 is a chloroform-extractable glycolipid
[edit] Proposed functions
CPS-500 is a candidate target antigen for active or passive immunization against cryptosporidiosis
[edit] Antigenic Nature used to produce antibodies
Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 18.44
[edit] Antibody type and class
IgG3
[edit] Assay System
ELISA, immunoblotting
[edit] Cross-reactivity
N/A
[edit] Proposed epitopes
the neutralization-sensitive epitope recognized by MAb 18.44 is dependent on terminal β-D-mannopyranosyl residues
[edit] Proposed Utility
MAb 18.44 neutralizes the infectivity of both sporozoites and merozoites and to significantly reduce C. parvum infection in oocyst-challenged mice when coadministered with other neutralizing Mab
