PolysacDB Capsular polysaccharide 1498
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Capsular polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Cryptococcus neoformans Serotype A [strain 24064]
[edit] Basic Structure
The major component of C. neoformans capsular polysaccharide is glucurunoxylomannan [GXM] consisting of an unbranched mannose backbone substituted with xylose, glucuronic acid and O-acetyl residues
[edit] Proposed functions
C. neoformans has a large polysaccharide capsule that is a determinant of virulence. The capsular polysaccharide causes immunologic paralysis and inhibits phagocytosis by macrophages. Soluble C. neoformans capsular polysaccharide enhances human immunodeficiency virus [HIV] infection in cultured cells, suggesting a new pathogenic role in AIDS
[edit] Antigenic Nature used to produce antibodies
Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 3B10
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA
[edit] Cross-reactivity
This antibody reacted with 2 serotype A strains 24064 and 371
[edit] Proposed epitopes
This Mab did not bind to de-O-acetylated GXM from both serotype A strains. This shows that acetylated residues form an important part of the epitope
[edit] Proposed Utility
N/A
