Parathyroid hormone-related protein precursor
From DrugPedia: A Wikipedia for Drug discovery
Contents |
[edit] Source Organism
Oryctolagus cuniculus (Rabbit).
[edit] Taxomomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;Oryctolagus.
[edit] Subcellular Localization
Cytoplasm (By similarity). Nucleus (By similarity). Secreted protein (By similarity).
[edit] Developmental Stage
[edit] Similarity
Belongs to the parathyroid hormone family.
[edit] Post translational Modification
There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions (By similarity).
[edit] Function
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differenciation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth (By similarity). Osteostatin is a potent inhibitor of osteoclastic bone resorption (By similarity).
