CarboDB Lipopolysaccharide 1457
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Haemophilus influenzae RM.7004
[edit] Basic Structure
It consists of an oligosaccharide linked via a 3-deoxy-D-manno-octulosonic acid (Kdo) residue to a lipid A region. The core is often divided into two regions: an inner core consisting of a heptose (Hep) and a Kdo residue and an outer core containing galactose (Gal) and glucose (Glc)
[edit] Proposed functions
LPS plays an important role in the infection process
[edit] Antigenic Nature used to produce antibodies
azide-killed H. influenzae RM.7004
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab MAHI 3
[edit] Antibody type and class
IgG2b
[edit] Assay System
enzyme immunoassay, colony dot immunoblotting, and immunoblotting
[edit] Cross-reactivity
MAHI 3 bound to all H. influenzae, all other human Haemophilus spp., all Bordetella pertussis and Bordetella parapertussis, and all Aeromonas spp. tested but not to any Neisseria or Moraxella catarrhalis strains
[edit] Proposed epitopes
The structural element recognized by MAHI 3 is Hepα1-->2Hepα1-->3Hepα1-->Kdo together with part of lipid A, including the phosphate
[edit] Proposed Utility
This Mab would help to detect the organism in environmental samples and clinical specimens
