CarboDB Gp40 glycoprotein 1377

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Gp40 glycoprotein

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Cryptosporidium parvum

[edit] Basic Structure

N/A

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

Fixed Cryptosporidium parvum sporozoites

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 4E9

[edit] Antibody type and class

IgM

[edit] Assay System

Immunofluorescence, immunoblotting

[edit] Cross-reactivity

This Mab did not react other protozoa (Giardia lamblia, E. Histolytica, Toxoplasma gondii, Trypanosoma cruzi, and L. major) and was specific for Cryptosporidium

[edit] Proposed epitopes

The epitope recognized by 4E9 contains α-N-acetylgalactosamine residues, which are present in a mucin-type O-glycosidic linkage

[edit] Proposed Utility

This MAb neutralized C. parvum infection and inhibited sporozoite attachment to intestinal epithelial cells in vitro

[edit] Weblink

PubMed Central

[edit] External Links

• Link to CarboDB database