CarboDB Core oligosaccharide 2318
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Core oligosaccharide
[edit] Carbohydrate Class
Core oligosaccharide [LPS]
[edit] Source Microbe
Shigella flexneri serotype 1b
[edit] Basic Structure
The core is a single sequence of heptoses and hexoses
[edit] Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
[edit] Antigenic Nature used to produce antibodies
Heat killed cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab MASF R3 core-1
[edit] Antibody type and class
IgG2a
[edit] Assay System
immunoblotting, enzyme-linked immunosorbent assay (ELISA), hemagglutination, and coagglutination
[edit] Cross-reactivity
The core-specific antibodies were shown to be specific for the Escherichia coli R3 core, which all S. flexneri LPSs were found to have, except for S. flexneri serotype 6 LPS
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab can be used for detection and identification of shigella flexneri species
