Androstanolone(DHT)
From DrugPedia: A Wikipedia for Drug discovery
Androstanolone(DHT) Pubchem(10635) A potent androgenic metabolite of TESTOSTERONE. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to ESTRADIOL therefore DHT is considered a pure androgenic steroid.
KEGG Pathway(C03917)
- Androgen and estrogen metabolism
- Prostate cancer
Activity Androgen
| MMDB ID | PDB ID | Reference |
|---|---|---|
| 13575 | 1D2S | Grishkovskaya I, Avvakumov GV, Sklenar G, Dales D, Hammond GL, Muller YACrystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domainEMBO J. v19, p.504-512 |
| 13985 | 1F5F | Avvakumov GV, Muller YA, Hammond GLSteroid-binding specificity of human sex hormone-binding globulin is influenced by occupancy of a zinc-binding siteJ. Biol. Chem. v275, p.25920-25925 |
| 19532 | 1KDK | Grishkovskaya I, Avvakumov GV, Hammond GL, Muller YAResolution of a disordered region at the entrance of the human sex hormone-binding globulin steroid-binding siteJ. Mol. Biol. v318, p.621-626 |
| 19533 | 1KDM | Grishkovskaya I, Avvakumov GV, Hammond GL, Muller YAResolution of a disordered region at the entrance of the human sex |
| 29012 | 1T73 | Hur E, Pfaff SJ, Payne ES, Gron H, Buehrer BM, Fletterick RJRecognition and accommodation at the androgen receptor coactivator binding interfacePLoS Biol. v2, p.E274 |
| 29013 | 1T74 | Hur E, Pfaff SJ, Payne ES, Gron H, Buehrer BM, Fletterick RJRecognition and accommodation at the androgen receptor |
| 29014 | 1T76 | Hur E, Pfaff SJ, Payne ES, Gron H, Buehrer BM, Fletterick RJRecognition and accommodation at the androgen receptor coactivator binding interfacePLoS Biol. v2, p.E274 |
| 29015 | 1T79 | Hur E, Pfaff SJ, Payne ES, Gron H, Buehrer BM, Fletterick RJRecognition and accommodation at the androgen receptor coactivator binding interfacePLoS Biol. v2, p.E274 |
| 29016 | 1T7F | Hur E, Pfaff SJ, Payne ES, Gron H, Buehrer BM, Fletterick RJRecognition and accommodation at the androgen receptor coactivator binding interfacePLoS Biol. v2, p.E274 |
| 29017 | 1T7M | Hur E, Pfaff SJ, Payne ES, Gron H, Buehrer BM, Fletterick RJRecognition and accommodation at the androgen receptor coactivator binding interfacePLoS Biol. v2, p.E274 |
| 29018 | 1T7R | Hur E, Pfaff SJ, Payne ES, Gron H, Buehrer BM, Fletterick RJRecognition and accommodation at the androgen receptor coactivator binding interfacePLoS Biol. v2, p.E274 |
| 29019 | 1T7T | Hur E, Pfaff SJ, Payne ES, Gron H, Buehrer BM, Fletterick RJRecognition and accommodation at the androgen receptor coactivator binding interfacePLoS Biol. v2, p.E274 |
| 31245 | 1T5Z | Estebanez-Perpina E, Moore JM, Mar E, Delgado-Rodrigues E, Nguyen P, Baxter JD, Buehrer BM, Webb P, Fletterick RJ, Guy RKThe molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptorJ. Biol. Chem. v280, p.8060-8068 |
| 31246 | 1T63 | Estebanez-Perpina E, Moore JM, Mar E, Delgado-Rodrigues E, Nguyen P, Baxter JD, Buehrer BM, Webb P, Fletterick RJ, Guy RKThe molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptorJ. Biol. Chem. v280, p.8060-8068 |
| 31247 | 1T65 | Estebanez-Perpina E, Moore JM, Mar E, Delgado-Rodrigues E, Nguyen P, Baxter JD, Buehrer BM, Webb P, Fletterick RJ, Guy RKThe molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptorJ. Biol. Chem. v280, p.8060-8068 |
| 31438 | 1XJ7 | Estebanez-Perpina E, Moore JM, Mar E, Delgado-Rodrigues E, Nguyen P, Baxter JD, Buehrer BM, Webb P, Fletterick RJ, Guy RKThe molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptorJ. Biol. Chem. v280, p.8060-8068 |
| 39038 | 2AMA | Pereira de Je, Cote PL, Cantin L, Blanchet J, Labrie F, Breton RComparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinityProtein Sci. v15, p.987-999 |
| 59291 | 2PIO | Estebanez-Perpina E, Arnold LA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJA surface on the androgen receptor that allosterically regulates coactivator bindingProc. Natl. Acad. Sci. U. S. A. v104, p.16074-16079 |
| 59292 | 2PIP | Estebanez-Perpina E, Arnold LA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJA surface on the androgen receptor that allosterically regulates coactivator bindingProc. Natl. Acad. Sci. U. S. A. v104, p.16074-16079 |
| 59293 | 2PIQ | Estebanez-Perpina E, Arnold LA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJA surface on the androgen receptor that allosterically regulates coactivator bindingProc. Natl. Acad. Sci. U. S. A. v104, p.16074-16079 |
| 59294 | 2PIR | Estebanez-Perpina E, Arnold LA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJA surface on the androgen receptor that allosterically regulates coactivator bindingProc. Natl. Acad. Sci. U. S. A. v104, p.16074-16079 |
| 59295 | 2PIT | Estebanez-Perpina E, Arnold LA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJA surface on the androgen receptor that allosterically regulates coactivator bindingProc. Natl. Acad. Sci. U. S. A. v104, p.16074-16079 |
| 59296 | 2PIU | Estebanez-Perpina E, Arnold LA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJA surface on the androgen receptor that allosterically regulates coactivator bindingProc. Natl. Acad. Sci. U. S. A. v104, p.16074-16079 |
| 59297 | 2PIV | Estebanez-Perpina E, Arnold LA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJA surface on the androgen receptor that allosterically regulates coactivator bindingProc. Natl. Acad. Sci. U. S. A. v104, p.16074-16079 |
| 59298 | 2PIW | Estebanez-Perpina E, Arnold LA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJA surface on the androgen receptor that allosterically regulates coactivator bindingProc. Natl. Acad. Sci. U. S. A. v104, p.16074-16079 |
| 59299 | 2PIX | Estebanez-Perpina E, Arnold LA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJA surface on the androgen receptor that allosterically regulates coactivator bindingProc. Natl. Acad. Sci. U. S. A. v104, p.16074-16079 |
| 59302 | 2PKL | Estebanez-Perpina E, Arnold LA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJA surface on the androgen receptor that allosterically regulates coactivator bindingProc. Natl. Acad. Sci. U. S. A. v104, p.16074-16079 |
| 59526 | 2QPY | Estebanez-Perpina E, Arnold LA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJA surface on the androgen receptor that allosterically regulates coactivator bindingProc. Natl. Acad. Sci. U. S. A. v104, p.16074-16079 |
| 61083 | 2Z4J | Jouravel N, Sablin E, Arnold LA, Guy RK, Fletterick RJInteraction between the androgen receptor and a segment of its corepressor SHPActa Crystallogr. D Biol. Crystallogr. v63, p.1198-1200 |
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 181 | deg C | EXP | |
| log P (octanol-water) | 3.55 (none) | EXP | ||
| Water Solubility | 5.25E+05 | mg/L | 25 | EXP |
| Vapor Pressure | 2.79E-08 | mm Hg | 25 | EST |
| Henry's Law Constant | 6.37E-09 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 4.17E-11 | cm3/molecule-sec | 25 | EST |
