Norepinephrine

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Description 2 General Properties 3 PhysioChemical Properties 4 External Links

Description

Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

As a stress hormone, norepinephrine affects parts of the brain where attention and responding actions are controlled. Along with epinephrine, norepinephrine also underlies the fight-or-flight response, directly increasing heart rate, triggering the release of glucose from energy stores, and increasing blood flow to skeletal muscle.

General Properties

*Molecular Weight

169.18

*Molecular Formula

C₈H₁₁NO₃

*IUPAC NAME

4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol

*Canonical Smiles

C1=CC(=C(C=C1C(CN)O)O)O

*Isomeric Smiles

C1=CC(=C(C=C1[C@H](CN)O)O)O

PhysioChemical Properties

*Melting Point

*LogP

*Water Solubility

External Links

• [1]Pubchem
• [2]KEGG Compound
• [3]KEGG Drug
• [4]Human Metabolome DataBase
• [5]Drugbank

Categories:Hormones