Obestatin-23
From DrugPedia: A Wikipedia for Drug discovery
Contents |
Description
Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin-23; Obestatin-13].
Source Organism
Rattus norvegicus (Rat).
Taxomomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
Subcellular Localization
Secreted protein.
Developmental Stage
Similarity
Belongs to the motilin family.
Post translational Modification
O-n-octanoylation is essential for ghrelin activity. The replacement of Ser-26 by aromatic tryptophan preserves ghrelin activity. Amidation of Leu-98 is essential for obestatin activity.
Function
Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
GeneID
59301
