Nuclear receptor subfamily 3 group C member 1;
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Contents |
Source Organism
Aotus nancymaae (Ma's night monkey).
Taxomomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Platyrrhini; Aotidae; Aotus.
Subcellular Localization
Cytoplasm (By similarity). Nucleus (By similarity). Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding (By similarity).
Developmental Stage
Similarity
Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Post translational Modification
Increased proteasome-mediated degradation in response to glucocorticoids (By similarity). Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoids (By similarity). Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling (By similarity). Sumoylated; this reduces transcription transactivation (By similarity).
Function
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity).
