Nuclear hormone receptor HR78
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 00:00, 15 January 2001 by Special:Contributions/ (Talk)
Contents |
Source Organism
Drosophila melanogaster (Fruit fly).
Taxomomy
Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;Ephydroidea; Drosophilidae; Drosophila.
Subcellular Localization
Nucleus.
Developmental Stage
Highest expression in third instar larvae and prepupae.
Similarity
Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Post translational Modification
Function
Binds to direct repeats of the sequence 5'-AGGTCA-3'. Inhibits the ecdysone response. Plays an essential role in regulating molting of the tracheal cuticle during larval development.
