Fluorometholone

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Description 2 General Properties 3 PhysioChemical Properties 4 External Links

Description

A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)

General Properties

*Molecular Weight

376.46

*Molecular Formula

C₂₂H₂₉FO₄

*IUPAC NAME

(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

*Canonical Smiles

CC1CC2C3CCC(C3(CC(C2(C4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)C)O

*Isomeric Smiles

C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@]2([C@@]4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)C)O

PhysioChemical Properties

*Melting Point

297(EXP)

*LogP

2(EXP)

*Water Solubility

30(EXP) at 25C

External Links

• [1]Pubchem
• [2]KEGG Drug
• [3]Drugbank

Categories:Hormones