Mechanistic Toxicology

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definition

Is a branch of Toxicology, which focuses on

  • Chemicals produce adverse effects
  • Biological systems protect themselves against adverse effects

Chemical research in toxicology usually investigates metabolic transformations of drugs or potentially hazardous chemicals.

Involves

  • Cellular and Molecular Biology
  • Chemistry, often xenobiotic metabolism

Questions asked by Mechanistic Toxicologist

  • How persistent is a chemical in the body?
  • Are metabolic products toxic?
  • Do test animals exhibit the same results as humans or other species of concern?
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