Cortisone

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Description 2 General Properties 3 PhysioChemical Properties 4 External Links

Description

A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)

General Properties

*Molecular Weight

360.44

*Molecular Formula

C₂₁H₂₈O₅

*IUPAC NAME

(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione

*Canonical Smiles

CC12CCC(=O)C=C1CCC3C2C(=O)CC4(C3CCC4(C(=O)CO)O)C

*Isomeric Smiles

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C

PhysioChemical Properties

*Melting Point

222(EXP)

*LogP

1.47(EXP)

*Water Solubility

280(EXP) at 25C

External Links

• [1]Pubchem
• [2]]3EB3,
• [3]]KEGG Compound
• [4]]KEGG Drug
• [5]Human Metabolome DataBase

Categories:Hormones