PolysacDB Capsular polysaccharide 2604

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Capsular polysaccharide

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Cryptococcus neoformans Serotype C

Basic Structure

The capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated

Proposed functions

The capsular polysaccharide is an important virulence factor

Antigenic Nature used to produce antibodies

Glycoconjugates

Carrier Name

Sheep erythrocytes

Conjugation Method

The capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature

Antibodies

Mab 3C2

Antibody type and class

N/A

Assay System

ELISA and Immunodiffusion

Cross-reactivity

This antibody cross-reacted with Serotype A,B,C and D serotypes

Proposed epitopes

N/A

Proposed Utility

used to differentiate various strains of all serotypes. This monoclonal antibody promoted opsonization of Cryptococcus cells

Weblink

PubMed

External Links

• BCSDB Structural Detail

• Link to PolysacDB database