PolysacDB Lipopolysaccharide 2548

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Vibrio cholerae 47-4041 serotype Ogawa

Basic Structure

The O-antigen part consists of (1-->2)-α-linked 4-amino-4,6-dideoxy-D-mannose (perosamine) whose amino group is acylated with 3-deoxy-L-glycero-tetronic acid. The terminal sugar in the Inaba O-antigen has a hydroxyl at the 2' position

Proposed functions

V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera

Antigenic Nature used to produce antibodies

Killed cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab OE7

Antibody type and class

IgG1

Assay System

slide or microdilution agglutination methods, along with enzyme-linked immunosorbent assays and immunoblotting analysis

Cross-reactivity

This Mab reacted with both Ogawa- and Inaba-type V. cholerae

Proposed epitopes

N/A

Proposed Utility

This Mab agglutinated only live and not heat killed Ogawa and Inaba cells

Weblink

PubMed

External Links

• Link to PolysacDB database