PolysacDB Lipopolysaccharide 2505
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
Lipopolysaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Vibrio cholerae 0139 serogroup
Basic Structure
The O-antigen part consists of (1-->2)-α-linked 4-amino-4,6-dideoxy-D-mannose (perosamine) whose amino group is acylated with 3-deoxy-L-glycero-tetronic acid. The terminal sugar in the Inaba O-antigen has a hydroxyl at the 2' position
Proposed functions
V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera
Antigenic Nature used to produce antibodies
acetone-treated whole cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab ICL11
Antibody type and class
IgG3
Assay System
enzyme-linked immunosorbent assay, slide agglutination test, motility inhibition test, and indirect immunofluorescence test
Cross-reactivity
This Mab was specific to V. cholerae O139. No cross-reactions were seen with LPS from V cholerae 01 Inaba and Ogawa serotypes
Proposed epitopes
N/A
Proposed Utility
All 86 cases diagnosed as V. cholerae 0139 by a rabbit polyclonal antiserum were also detected by this MAb, establishing its utility as highly sensitive and specific diagnostic reagent
