Desoxycortone

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Desoxycortone(Deoxycorticosterone)

Pubchem(6166)

21-Hydroxypregn-4-ene-3,20-dione. Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.

KEGG Pathway(C03205,D07792)

Activity Adrenal cortex hormone, mineralocorticoid

**List of PDB files having estriol as a Ligand:**
MMDB ID	PDB ID	Reference
33237	1Y9R	Fagart J, Huyet J, Pinon GM, Rochel M, Mayer C, Rafestin-Oblin MECrystal structure of a mutant mineralocorticoid receptor responsible for hypertensionNat. Struct. Mol. Biol. v12, p.554-555
34430	2AA7	Bledsoe RK, Madauss KP, Holt JA, Apolito CJ, Lambert MH, Pearce KH, Stanley TB, Stewart EL, Trump RP, Willson TM, Williams SPA ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptorJ. Biol. Chem. v280, p.31283-31293
59380	2Q3Y	Ortlund EA, Bridgham JT, Redinbo MR, Thornton JWCrystal structure of an ancient protein: evolution by conformational epistasisScience v317, p.1544-1548

**Physiochemical properties of Estradiol:**
Physical Property	Value	Units	Temp (deg C)	Source
Melting Point	141.5	deg C		EXP
log P (octanol-water)	2.88	(none)		EXP
Water Solubility	59.5	mg/L	37	EXP
Vapor Pressure	2.85E-10	mm Hg	25	EST
Henry's Law Constant	1.01E-08	atm-m3/mole	25	EST
Atmospheric OH Rate Constant	1.07E-10	cm3/molecule-sec	25	EST

**Toxicity:**
Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	unreported	1gm/kg (1000mg/kg)		Journal of Medicinal Chemistry. Vol. 7, Pg. 673, 1964.