PolysacDB Ssp-4 (amastigote surface glycoprotein) 2492

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Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Ssp-4 (amastigote surface glycoprotein)

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Trypanosoma cruzi amastigotes

[edit] Basic Structure

Ssp-4 is an amastigote-specific 84 KDa surface component defined by monoclonal antibody (MAb) 2C2, that was shown to be linked to the membrane by a GPI anchor. The epitope defined by MAb 2C2 is homogeneously distributed over the amastigote surface throughout the intracellular life cycle until it is gradually shed through a phospholipase-dependent mechanism during transformation into trypomastigote

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

psoralen/UV-inactivated intracellular amastigotes

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 2B7

[edit] Antibody type and class

IgG3

[edit] Assay System

ELISA, immunoblotting, immuno-electron microscopy and confocal immunofluorescence

[edit] Cross-reactivity

N/A

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This Mab reacted with cytoplasmic membrane-bound compartments of the amastigotes

[edit] Weblink

PubMed

[edit] External Links

• Link to PolysacDB database