PolysacDB 35 and 50 KDa surface glycoconjugates 2489

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

35 and 50 KDa surface glycoconjugates

Carbohydrate Class

Miscellaneous

Source Microbe

Trypanosoma cruzi strain G

Basic Structure

N/A

Proposed functions

These glycoconjugates may play an important role in the metacyclic form-host cell association that initiates T. cruzi infection

Antigenic Nature used to produce antibodies

Killed strain G metacyclic forms

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 10D8

Antibody type and class

N/A

Assay System

ELISA, immunoblotiing, parasite invasion assay

Cross-reactivity

10D8 was found to react with metacyclic trypomastigotes from triatomine or from culture as well as with epimastigotes but not with tissue amastigotes or blood trypomastigotes

Proposed epitopes

N/A

Proposed Utility

The invasion of Vero cells by metacyclic forms of strains Tulahuen and G was inhibited 50 to 67% in the presence of 10D8. Mice that had passively received 10D8 before challenge with metacyclic forms, a considerable decrease in the parasitemia levels was observed

Weblink

PubMed Central

External Links

• Link to PolysacDB database