PolysacDB Lipopolysaccharide 2447

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Shigella flexneri serotype Y

Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -3)-α-D-GlcpNAc-(1-->3)-β-L-Rhap-(1-->2)-α-L-Rhap-(1-->2)-β-L-Rhap-(1-

Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

Antigenic Nature used to produce antibodies

Phenol killed cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab MASF-2

Antibody type and class

IgG1

Assay System

ELISA, immunodiffusion

Cross-reactivity

This Mab was specific to Y-LPS

Proposed epitopes

MASFY-2 exhibits distinct preference for the oligosaccharide α-L-Rha(1-->2)α-L-Rha(1-->3)α-L-Rha(1-->3)βGlcNac repeating as a dimer

Proposed Utility

This Mab can be used for antigenic characterization of Shigella LPS

Weblink

PubMed

External Links

• BCSDB Structural Detail

• IEDB Epitopic Detail

• Link to PolysacDB database