PolysacDB Lipopolysaccharide 2445

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Shigella flexneri serotype Y

[edit] Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -3)-α-D-GlcpNAc-(1-->3)-β-L-Rhap-(1-->2)-α-L-Rhap-(1-->2)-β-L-Rhap-(1-

[edit] Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

[edit] Antigenic Nature used to produce antibodies

Phenol killed cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab Y-B5

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA, immunodiffusion

[edit] Cross-reactivity

This Mab was highly cross-reactive and cross-reacted with 1b, 2b, 3a, 4a and X LPS

[edit] Proposed epitopes

This Mab reacted with alkali-treated LPS

[edit] Proposed Utility

This Mab can be used for antigenic characterization of Shigella LPS

[edit] Weblink

PubMed

[edit] External Links

• BCSDB Structural Detail

• IEDB Epitopic Detail

• Link to PolysacDB database