PolysacDB Lipoteichoic acids (LTAs) 2401
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipoteichoic acids (LTAs)
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Streptococcus mutans Ingbritt
[edit] Basic Structure
LTAs are amphiphiles composed of a membrane lipid or glycolipid which is covalently linked to a linear chain of 15 to 30 polyglycerophosphate (PGP) units
[edit] Proposed functions
Lipoteichoic acids (LTAs) are present on the surfaces of a majority of gram-positive bacteria and have been shown to constitute 1 to 2% of the dry weight of several organisms
[edit] Antigenic Nature used to produce antibodies
Ethylene oxide killed cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 7B11
[edit] Antibody type and class
IgG3
[edit] Assay System
Haemagglutination
[edit] Cross-reactivity
This Mab cross-reacted with LTA from L.casei 6375 and L. fermentum but was relatively less efficient in its ability to interact with the LTAs of S. faecium
[edit] Proposed epitopes
Glycerophosphate-glycerophosphateglycerol residue backbone seemed to be an important part of the epitope
[edit] Proposed Utility
These highly specific reagents [Mabs] should prove useful not only for affinity purification of LTAs but also for experiments designed to define the putative role(s) of LTAs in biological processes
