PolysacDB Lipoteichoic acids (LTAs) 2398

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipoteichoic acids (LTAs)

Carbohydrate Class

Miscellaneous

Source Microbe

Streptococcus mutans BHT

Basic Structure

LTAs are amphiphiles composed of a membrane lipid or glycolipid which is covalently linked to a linear chain of 15 to 30 polyglycerophosphate (PGP) units

Proposed functions

Lipoteichoic acids (LTAs) are present on the surfaces of a majority of gram-positive bacteria and have been shown to constitute 1 to 2% of the dry weight of several organisms

Antigenic Nature used to produce antibodies

Ethylene oxide killed cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 8G10

Antibody type and class

IgM

Assay System

Haemagglutination

Cross-reactivity

This Mab cross-reacted with LTA from L.casei 6375 and also to some extent with the LTAs of L. fermentum and S. faecium

Proposed epitopes

Glycerophosphate-glycerophosphateglycerol residue backbone seemed to be an important part of the epitope

Proposed Utility

These highly specific reagents [Mabs] should prove useful not only for affinity purification of LTAs but also for experiments designed to define the putative role(s) of LTAs in biological processes

Weblink

PubMed Central

External Links

• Link to PolysacDB database