PolysacDB Lipopolysaccharide 2352

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Sinorhizobium meliloti strain NRG185

[edit] Basic Structure

There are two forms of LPS: rough LPS (R-LPS), which consists of a lipid A membrane anchor and conserved core oligosaccharides, and smooth LPS (S-LPS), which includes the O-antigen (or O-polysaccharide)

[edit] Proposed functions

LPS is an important surface antigen

[edit] Antigenic Nature used to produce antibodies

Whole cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 11

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA and immunoblotting

[edit] Cross-reactivity

This Mab was highly cross-reactive recognizing most number of Shinorhizobium species. MAb 11 recognized only one major form (band) of R-LPS from the serogroup A strains, and it did not bind the S-LPS from any strain

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

The use of MAbs to study specific cell surface components from the bacteroids of Rhizobium leguminosarum have yielded interesting information about morphogenesis in the pea symbiont, including the temporal expression of specific epitopes during nodule development

[edit] Weblink

PubMed

[edit] External Links

• Link to PolysacDB database