PolysacDB Lipopolysaccharide 2307
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
Lipopolysaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Shigella flexneri serotype 2a
Basic Structure
Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->
Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodies
Whole cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab C1-7
Antibody type and class
IgG3
Assay System
ELISA, protection experiments
Cross-reactivity
This Mab cross-reacted with S. flexneri serotype X, Y, 5a, 5b, 2a, 2b, 1a, 3a
Proposed epitopes
This Mab recognized the pentasaccharide L-rhamnose-L-rhamnose-α-D-glucose-L-rhamnose-N-acetyl-D-glucosamine
Proposed Utility
N/A
