PolysacDB Lipopolysaccharide 2306
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Shigella flexneri serotype 2a
[edit] Basic Structure
Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->
[edit] Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
[edit] Antigenic Nature used to produce antibodies
Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab E4-1
[edit] Antibody type and class
IgG2b
[edit] Assay System
ELISA, protection experiments
[edit] Cross-reactivity
This Mab cross-reacted with S. flexneri serotype X, Y, 5a, 5b, 2a, 2b, 1a, 3a
[edit] Proposed epitopes
This Mab recognized the tetrasaccharide L-rhamnose-α-D-glucose-L-rhamnose-N-acetyl-D-glucosamine
[edit] Proposed Utility
This Mab showed invivo protection
