PolysacDB O-polysaccharide 2293

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

O-polysaccharide

Carbohydrate Class

O-polysaccharide [LPS]

Source Microbe

Shigella dysenteriae

Basic Structure

Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Heat killed cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 3707 E9

Antibody type and class

IgM

Assay System

ELISA and immunoblotting

Cross-reactivity

N/A

Proposed epitopes

rhamnopyranosyl-α-( 1-->2)-galactopyranosyl disaccharide seemed to be the major antigenic determinanant

Proposed Utility

This Mab can help in the identification of immunodominant epitope in the O-antigen of Shigella dysenteriae LPS

Weblink

PubMed

External Links

• IEDB Epitopic Detail

• Link to PolysacDB database