PolysacDB LDN-DF along with fucosylated LDN 2243

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

LDN-DF along with fucosylated LDN

Carbohydrate Class

Miscellaneous

Source Microbe

Schistosoma mansoni

Basic Structure

This carbohydrate consists of N-linked glycans containing GalNAc-β-1-->4[Fucα1-->2Fucα 1-->3]GLcNAc

Proposed functions

These carbohydrate structures are mainly involved in immune evasion

Antigenic Nature used to produce antibodies

Glycoconjugates

Carrier Name

Bovine serum albumin

Conjugation Method

The spacer linked oligosaccharides were converted to their N-hydroxysuccinimido-ester complexes and conjugated to amino groups on BSA

Antibodies

Mab 294-2A1

Antibody type and class

IgM

Assay System

ELISA, indirect immunfluorescence and surface plasmon resonance

Cross-reactivity

This Mab was highly specific and did not show cross-reactivity to other carbohydratge epitopes

Proposed epitopes

This Mab was directed to epitopes mainly present on the excretory system, on miracidia, and on the whole cercariae

Proposed Utility

This Mab may lead to a better understanding of the function of glycans

Weblink

PubMed

External Links

• Link to PolysacDB database