PolysacDB Lipopolysaccharide 2230

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Salmonella typhimurium SL 1102 [Re]

Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain

Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

Antigenic Nature used to produce antibodies

Heat killed bacteria

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab MAST5

Antibody type and class

IgG3

Assay System

Enzyme immunoassay

Cross-reactivity

This Mab cross-reacted with Rd2 LPS

Proposed epitopes

3-deoxy-D-mannooctulosonic acid [KDO] residues at the terminal non-reducing ends seemed to be the part of the epitope. The particular epitope was proposed to be α-Kdo[2-->4] Kdo

Proposed Utility

This Mab would help elucidate the Kdo LPS domain structure

Weblink

PubMed

External Links

• Link to PolysacDB database