PolysacDB O-polysaccharide 2179

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

O-polysaccharide

[edit] Carbohydrate Class

O-polysaccharide [LPS]

[edit] Source Microbe

Salmonella typhimurium

[edit] Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -2)-α-D-Manp [branched to α-Abep-(1-->3)] -(1-->4)-α-L-Rhap-(1-->3)-α-D-Galp-(1-

[edit] Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

[edit] Antigenic Nature used to produce antibodies

Whole cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 5A5

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA, immunoblotting, dot blot assay, immunoelectron microscopy

[edit] Cross-reactivity

This Mab reacted with S. typhimurium (LPS O:1, 4, 5, and 12) while failing to recognize S. typhimurium var. copenhagen (LPS O:1, 4, and 12). It reacted equally with live and heat-attenuated Salmonella B serovars containing LPS O-5 antigen

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This Mab can be used to discriminate between S. typhimurium and S. typhimurium var. copenhagen

[edit] Weblink

PubMed Central

[edit] External Links

• BCSDB Structural Detail

• Link to PolysacDB database