PolysacDB Lipopolysaccharide 2174
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
Lipopolysaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Salmonella paratyphi A
Basic Structure
LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -2)-α-D-Manp [branched to α-Parp-(1-->3)] -(1-->4)-α-L-Rhap-(1-->3)-α-D-Galp [branched to α-D-Glcp-(1-->4)] -(1-
Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodies
Formalin fixed cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab MO2
Antibody type and class
IgG1
Assay System
ELISA, immunoblotting
Cross-reactivity
This Mab was specific to lipopolysaccharide of Salmonella paratyphi A, and did not react against lipopolysaccharides of other Salmonella serogroups, including those of serogroups B, C, D, E, and L
Proposed epitopes
Dideoxyhexose residues are believed to be the immunodominant epitope for Mab M02
Proposed Utility
This Mab can facilitate the routine identification of salmonella and detailed studies of their lipopolysaccharides
