PolysacDB Lipopolysaccharide 2074

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Pseudomonas aeruginosa

Basic Structure

The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Healthy or infected patients

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 2H9

Antibody type and class

IgG1

Assay System

ELISA, opsonophagocytic assays, animal protection studies

Cross-reactivity

N/A

Proposed epitopes

N/A

Proposed Utility

This Mab had invivo protective capacity against experimental pseudomonas infection

Weblink

PubMed Central

External Links

• Link to PolysacDB database