Cortisol

From DrugPedia: A Wikipedia for Drug discovery

Hydrocortisone(Cortisol)

Pubchem(5754)

The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

Lipinski’s “Rule of Five” Prediction for a Compound’s ABSORPTION OR PERMEABILITY PROPERTIES 4 GOOD 3 INDETERMINATE 2 INDETERMINATE 1 INDETERMINATE 0 POOR

Pathway(C00735,D00088) C21-Steroid hormone metabolism Neuroactive ligand-receptor interaction Prostate cancer

Target glucocorticoid receptor Activity Glucocorticoid

|59369 |2Q1V |Ortlund EA, Bridgham JT, Redinbo MR, Thornton JWCrystal structure of an ancient protein: evolution by conformational epistasisScience v317, p.1544-1548 |- |59811 |2V95 |Klieber MA, Underhill C, Hammond GL, Muller YACorticosteroid-binding globulin, a structural basis for steroid transport and proteinase-triggered releaseJ. Biol. Chem. v282, p.29594-29603 |- |64401 |2VDY |Zhou A, Wei Z, Stanley PL, Read RJ, Stein PE, Carrell RWThe S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone releaseJ. Mol. Biol. v380, p.244-251 |- |}

|Melting Point |220 |deg C | |EXP |- |Water Solubility |320 |mg/L |25 |EXP |- |Vapor Pressure |1.35E-13 |mm Hg |25 |EST |- |Henry's Law Constant |5.77E-08 |atm-m3/mole |25 |EST |- |Atmospheric OH Rate Constant |1.14E-10 |cm3/molecule-sec |25 |EST |-

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source |man |TDLo |oral |400mg/kg/10D- (400mg/kg) |BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS |Psychopharmacology Vol. 145, Pg. 260, 1999. |- |mouse |LD50 |subcutaneous |> 500mg/kg (500mg/kg) |Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(3), Pg. 26, 1990. |rat |LD50 |intraperitoneal |150mg/kg (150mg/kg) |Japanese Journal of Pharmacology. Vol. 21, Pg. 377, 1971. |- |rat |LD50 |subcutaneous |449mg/kg (449mg/kg) |Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966. |- |}