PolysacDB Lipopolysaccharide 2030

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Pseudomonas aeruginosa

[edit] Basic Structure

The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

Heat killed Whole cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab P6-2A2

[edit] Antibody type and class

IgG2a

[edit] Assay System

ELISA, immunoblotting, opsonophagocytic assay and in vivo protection assay

[edit] Cross-reactivity

This Mab reacted with strains Fisher IT-1, 06a,6b, and 06a,6d and did not react with strain 06a, 6c

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This Mab demonstrated opsonophagocytic killing of 06 subtype strains in the presence of human peripheral blood leukocytes and fresh human serum. This Mab also showed in vivo protection

[edit] Weblink

PubMed Central

[edit] External Links

• Link to PolysacDB database