Tipepidine citrate

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Tipepidine (Bithiodine, Sotal, Antupex, Asverin) is a centrally-acting cough suppressant of the opioid type. It is a member of the thiambutene series of open-chain (methadone-related) synthetic opioids, which include Ohton (dimethylthiambutene), a strong narcotic analgesic used particularly in veterinary medicine in Japan and other East Asian countries. It was developed in Japan in 1959 and is used as the citrate and hibenzate salts. The usual dose is 20 mg every 4–6 hours. Its relative weakness and other properties make it a drug which is not controlled in most countries or internationally.

[edit] Synonyms

  • Tipepidine citrate
  • Tipepidine citrate (JAN)
  • D02023
  • 14698-07-8

[edit] Properties

Molecular Weight467.5557 [g/mol]
Molecular FormulaC21H25NO7S2
H-Bond Donor4
H-Bond Acceptor8
Rotatable Bond Count7
Exact Mass467.107244
MonoIsotopic Mass467.107244
Topological Polar Surface Area135
Heavy Atom Count31
Formal Charge0
Complexity536
Isotope Atom Count0
Defined Atom StereoCenter Count0
Undefined Atom StereoCenter Count0
Defined Bond StereoCenter Count0
Undefined Bond StereoCenter Count0
Covalently-Bonded Unit Count2