Amrinone

From DrugPedia: A Wikipedia for Drug discovery

Amrinone (INN) or inamrinone, trade name Inocor, is a type 3 pyridine phosphodiesterase inhibitor.

It is used in the treatment of congestive heart failure.

Contents 1 Class 2 Actions 3 Indications 4 Contraindications 5 Precautions 6 Side effects 7 Routes 8 Pediatric dosage

[edit] Class

Cardiac inotrope.

[edit] Actions

Increases cardiac contractility, vasodilator. Acts by inhibiting the breakdown of both cAMP and cGMP

[edit] Indications

Short-term management of severe CHF.

[edit] Contraindications

Patients with history of hypersensitivity to the drug.

[edit] Precautions

May increase myocardial ischemia. Blood pressure, pulse, and EKG should be constantly monitored. Amrinone should only be diluted with normal saline or 1/2 normal saline; no dextrose solutions should be used. Furosemide should not be administered into an IV line delivering Amrinone.

[edit] Side effects

Reduction in platelets, nausea and vomiting cardiac arrhythmias.

[edit] Routes

IV bolus and infusion as described earlier.

[edit] Pediatric dosage

Safety in children has not been established