PolysacDB N-propionylated group B meningococcal polysaccharide 1793

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

N-propionylated group B meningococcal polysaccharide

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Neisseria meningitidis

Basic Structure

It consists of a homopolymer of α(2-->8)-linked sialic acid residues

Proposed functions

It is an important virulence factor

Antigenic Nature used to produce antibodies

Glycoconjugates

Carrier Name

Tetanus toxoid

Conjugation Method

N-propionylated group B meningococcal polysaccharide was combined with freshly purified monomeric tetanus toxoid in a solution of phosphate buffer containing NaBH3CN and incubated at 37C for 5 days

Antibodies

Mab 6B9

Antibody type and class

IgG2a

Assay System

ELISA, bactericidal assays

Cross-reactivity

N/A

Proposed epitopes

The epitope was located only on extended helical segments of the polysaccharide and also comprised short internal fragments

Proposed Utility

This Mab would help in the elucidation of the capsular polysaccharide structure

Weblink

PubMed Central

External Links

• Link to PolysacDB database