PolysacDB N-propionylated group B meningococcal polysaccharide 1792

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

N-propionylated group B meningococcal polysaccharide

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Neisseria meningitidis

Basic Structure

It consists of a homopolymer of α(2-->8)-linked sialic acid residues

Proposed functions

It is an important virulence factor

Antigenic Nature used to produce antibodies

Glycoconjugates

Carrier Name

Tetanus toxoid

Conjugation Method

N-propionylated group B meningococcal polysaccharide was combined with freshly purified monomeric tetanus toxoid in a solution of phosphate buffer containing NaBH3CN and incubated at 37C for 5 days

Antibodies

Mab 13D9

Antibody type and class

IgG2a

Assay System

ELISA, bactericidal assays

Cross-reactivity

N/A

Proposed epitopes

The epitope was located only on extended helical segments of the polysaccharide

Proposed Utility

This Mab had bactericidal activity

Weblink

PubMed Central

External Links

• Link to PolysacDB database