Amrinone

From DrugPedia: A Wikipedia for Drug discovery

Amrinone (INN) or inamrinone, trade name Inocor, is a type 3 pyridine phosphodiesterase inhibitor.

It is used in the treatment of congestive heart failure.

Contents 1 Class 2 Actions 3 Indications 4 Contraindications 5 Precautions 6 Side effects 7 Routes 8 Pediatric dosage

Class

Cardiac inotrope.

Actions

Increases cardiac contractility, vasodilator. Acts by inhibiting the breakdown of both cAMP and cGMP

Indications

Short-term management of severe CHF.

Contraindications

Patients with history of hypersensitivity to the drug.

Precautions

May increase myocardial ischemia. Blood pressure, pulse, and EKG should be constantly monitored. Amrinone should only be diluted with normal saline or 1/2 normal saline; no dextrose solutions should be used. Furosemide should not be administered into an IV line delivering Amrinone.

Side effects

Reduction in platelets, nausea and vomiting cardiac arrhythmias.

Routes

IV bolus and infusion as described earlier.

Pediatric dosage

Safety in children has not been established