PolysacDB Phenolic glycolipid-I 1731

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Phenolic glycolipid-I

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Mycobacterium leprae

[edit] Basic Structure

Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose

[edit] Proposed functions

It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy

[edit] Antigenic Nature used to produce antibodies

Whole cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 1-24

[edit] Antibody type and class

N/A

[edit] Assay System

Inhibitory ELISA

[edit] Cross-reactivity

This Mab recognized the outer (nonreducing end) monosaccharide of the trisaccharide chain of PGL-I

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy

[edit] Weblink

PubMed

[edit] External Links

• IEDB Epitopic Detail

• Link to PolysacDB database