PolysacDB Glycopeptidolipid antigen 1667

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1 Carbohydrate Name
2 Carbohydrate Class
3 Source Microbe
4 Basic Structure
5 Proposed functions
6 Antigenic Nature used to produce antibodies
7 Carrier Name
8 Conjugation Method
9 Antibodies
10 Antibody type and class
11 Assay System
12 Cross-reactivity
13 Proposed epitopes
14 Proposed Utility
15 Weblink
16 External Links

[edit] Carbohydrate Name

Glycopeptidolipid antigen

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Mycobacterium avium complex serovar 4

[edit] Basic Structure

This antigen is composed of a glycosylated lipopeptide core, fatty acyl-D-phenylalanine-D-allothreonine-D-alanine-L-alaninyl-O-(3,4-di-O-methyl-α-L-rhamnopyranoside), to which a haptenic oligosaccharide is linked at the threonine substituent

[edit] Proposed functions

This oligosaccharide unit is the source of the dominant immunogenicity of members of the M. avium complex, i.e., their characteristic agglutinability and type specificity

[edit] Antigenic Nature used to produce antibodies

serovar 4-specific neoglycoprotein, 4-0-methyl-a-L-rhamnopyranosyl(1--> 4)-2-0 - methyl - alpha - L fucopyranosyl oxynonanoyl-bovine serum albumin (BSA) (neoantigen 4) along with whole washed M. avium complex serovar 4 cells and corresponding serovar 4 glycopeptidolipid antigens

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab F85-3

[edit] Antibody type and class

IgG3

[edit] Assay System

ELISA, Inhibition assays, dot blot

[edit] Cross-reactivity

This antibody cross-reacted with whole cells of serovar 4 and acetylated-GPL-4

[edit] Proposed epitopes

4-O-methyl-α-L-rhamnopyranosyl-(1-->4)-2-O-methyl-α-L-fucopyranosyl residues seemed to be a part of the epitope

[edit] Proposed Utility

This Mab can be used for the identification and classification of M. avium isolates. This Mab can be applied directly to bacterial cultures, thus allowing easy, rapid identification of at least half of the M. avium isolates encountered in the clinical laboratory